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Golgin-97 golgin-245 and rabkinesin-6: effector proteins for the small GTPases rab6a and rab6b during membrane traffic in mammalian cells
Reference
C12901
Principal Investigator / Supervisor
Professor Francis Barr
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
IBLS Division of Biochemistry & Molecula
Funding type
Research
Value (£)
8,021
Status
Completed
Type
Research Grant
Start date
01/04/2000
End date
01/04/2003
Duration
36 months
Abstract
The small GTPase rab6 interacts with a number of different effector proteins, including golgin-97, golgin-245, and rabkinesin-6. Golgin-97 and golgin-245 have conserved regions at their C-termini; the rab6 binding GRIP domain, and their basic N-termini. Coiled-coil proteins related in structure to these two golgins are also able to interact with specific rabs function in vesicle docking in the endocytic pathway. These proteins interact with different effectors at each end, something that is likely to be the case for golgin-97 and golgin-245. The identification of a second form of rab6 in mammalian cells which differs in its putative effector binding region, raises questions as to the specificity of the known rab6 effectors and to the functions they play in membrane transport. The aim of this work is to further characterise golgin-97 and golgin-245 as rab6 effector proteins.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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