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The role of phosphoinositide 3-kinase(s) in chemokine mediated signal transduction and chemotaxis
Reference
C12884
Principal Investigator / Supervisor
Professor Stephen Ward
Co-Investigators /
Co-Supervisors
Institution
University of Bath
Department
Pharmacy and Pharmacology
Funding type
Research
Value (£)
152,304
Status
Completed
Type
Research Grant
Start date
05/06/2000
End date
05/06/2003
Duration
36 months
Abstract
Several chemokines are now known to activate the PI3K signalling pathway which has been linked to the triggering of a diverse array of cellular responses. Our preliminary studies have indicated that the CXC chemokine Stromal cell-Derived Factor (SDF-1) stimulates the accumulation of D-3 phosphoinositides (the products of PI3K activation), whilst PI3K inhibitors prevent SDF-1 stimulated chemotaxis. This study proposes to identify (i) the class of PI3K responsible for the formation of these D-3 lipids and (ii) the downstream biochemical and functional targets of this pathway, using dominant negative mutants of the p85/p110 heterodimeric PI3K and the Gi-coupled p110gamma in a controlled inducible gene expression system.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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