Award details

Enzymology of soluble guanylate cyclase: expressional regulation cellular localisation & modulation by nitric oxide

Reference	C12878
Principal Investigator / Supervisor	Professor Adrian Hobbs
Co-Investigators / Co-Supervisors	Professor Ian Charles, Professor Kenneth Powell
Institution	University College London
Department	The Wolfson Inst for Biomedical Research
Funding type	Research
Value (£)	185,468
Status	Completed
Type	Research Grant
Start date	01/04/2000
End date	01/01/2005
Duration	57 months

Abstract

Soluble guanylate cyclase (sGC) acts as the intracellular receptor for nitric oxide (NO). Inappropriate activity of this signalling pathway has been implicated in the aetiology of numerous diseases including impotence, stroke and neurodegenerative disorders. Due to the difficulty in obtaining significant quantities of purified sGC protein, and the complex structure of the enzyme, it has proven rather intractable to conventional molecular & biochemical analysis. Consequently, there is relatively little data on the expressional & biochemical regulation of the enzyme; the role(s) of the various isoforms in health and disease is also unknown. This proposal will address these points and investigate mechanisms underlying enzyme activation by NO.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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