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Investigations of cell surface interactions of CD14
Reference
C12823
Principal Investigator / Supervisor
Professor Richard Cherry
Co-Investigators /
Co-Supervisors
Professor Nelson Fernández
Institution
University of Essex
Department
Biological Sciences
Funding type
Research
Value (£)
190,604
Status
Completed
Type
Research Grant
Start date
10/12/1999
End date
10/05/2003
Duration
41 months
Abstract
The presence of lipopolysaccharide (LPS) from Gram-negative bacteria signals the innate immune system to upregulate bacterial clearance and activates cells to release inflammatory mediators. These events are triggered by binding of LPS to either membrane- bound CD14 (mCD14) or soluble CD14 (sCD14). Single particle fluorescence imaging (SPFI) will be employed to investigate various cell surface events that are relevant to LPS internalisation and cell activation. Experiments will be performed to determine the organisation and mobility of mCD14 and events that follow LPS binding to mCD14. The involvement to cell activation of LAP1, a cellular protein that coprecipitates with LPS, will also be investigated.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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