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Downregulation of tyrosine kinase receptors
Reference
C12794
Principal Investigator / Supervisor
Dr Nicholas Dibb
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Electrical and Electronic Engineering
Funding type
Research
Value (£)
164,998
Status
Completed
Type
Research Grant
Start date
01/05/2000
End date
01/05/2003
Duration
36 months
Abstract
The downregulation of tyrosine kinase receptors is thought to be dependent upon intrinsic receptor kinase activity, largely because downregulation is inhibited by a kinase-inactivating mutation of an invariant lysine residue of all tested receptors. We recently identified kinase- inactive M-CSF receptors that are normally downregulated in response to ligand, so demonstrating that kinase activity is not essential for this process. Here it is proposed to establish that tyrosine kinase receptor downregulation in general is initiated by structural changes of the activating-loop of the kinase domain, so ensuring that receptor downregulation is coupled to but it not necessarily dependent upon receptor kinase activity and signalling.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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