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Golgi apparatus dynamics during interphase and metaphase studied using a novel in vitro assay
Reference
C12788
Principal Investigator / Supervisor
Professor Viki Allan
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
186,076
Status
Completed
Type
Research Grant
Start date
25/07/2000
End date
25/07/2003
Duration
36 months
Abstract
The Golgi apparatus is a highly dynamic organelle whose position and organisation within the cell is likely to reflect a balance between the activities of plus end- and minus end- directed microtubule motors associated with its surface. During mitosis, the structure and function of the Golgi apparatus changes dramatically, and it may no longer move along microtubules. We have reconstituted the assembly of the motile Golgi stacks in vitro using Xenopus egg extracts, and will use this system to: 1) investigate Golgi apparatus dynamics and motility in interphase; and 2) ascertain whether these properties change on entry into metaphase; and whether cytoplasmic dynein is associated with Golgi apparatus membranes in metaphase.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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