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Structure-function analysis of Scp 1p a calponin homologue in budding yeast
Reference
C12769
Principal Investigator / Supervisor
Professor Kathryn Ayscough
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
Veterinary School
Funding type
Research
Value (£)
193,320
Status
Completed
Type
Research Grant
Start date
08/03/2000
End date
08/03/2003
Duration
36 months
Abstract
The identification of a homologue of this calponin family, in budding yeast provides the opportunity to study this protein in a well characterised and manipulable system. The high level of conservation among actin binding proteins and their effects on the actin cytoskeleton indicates that the fundamental role of Scp 1p is likely to have been maintained across eukaryotic evolution. We will undertake in vivo genetic approaches including a screen to identify suppressors of its overexpression phenotype and complementary in vitro approaches which will focus on the interactions of Scp 1p with actin. Our research will allow us to identify important binding domains which mediate interactions with actin and such results are likely to be directly applicable and facilitate future studies on the role of these proteins in both muscle and non-muscle cells.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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