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A molecular analysis of the processing of the beta-amyloid precursor protein at the endoplasmic reticulum

Reference	C12755
Principal Investigator / Supervisor	Professor Stephen High
Co-Investigators / Co-Supervisors
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	199,552
Status	Completed
Type	Research Grant
Start date	01/10/2000
End date	30/04/2004
Duration	43 months

Abstract

Alzheimer's disease is characterised by amyloid plaques present in the brain. The Ab peptides, Ab40 and Ab42 are major components of these plaques and they are widely believed to play a causal role during the development of Alzheimer's disease. The Ab peptides are generated by the proteolytic processing of the beta-amyloid precursor protein, the generation of Ab42 being of major significance since it is the most amyloidogenic. Ab42 is generated at the endoplasmic reticulum via a pathway that is poorly characterised at the molecular level. The aim of this project is to identify the ER components responsible for the production of Ab42 and define the molecular details of the pathway by which it is produced. This will be achieved using well established cross-linking techniques.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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