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Myosin function and the control of neuronal growth cone motility
Reference
C12647
Principal Investigator / Supervisor
Professor Peter Duncan Chantler
Co-Investigators /
Co-Supervisors
Institution
Royal Veterinary College
Department
Veterinary Basic Sciences - London
Funding type
Research
Value (£)
191,932
Status
Completed
Type
Research Grant
Start date
01/02/2000
End date
01/02/2003
Duration
36 months
Abstract
Myosin function, during the complex process of neuronal growth cone protrusion, remains unknown. We hypothesise that individual myosin isoforms perform separate and distinct tasks during neurite outgrowth, retraction and focal contact formation, the division of labour being ensured through separate control mechanisms. Having successfully used a functional knockout approach to implicate myosin IIB in neurite outgrowth, we have developed the tools necessary to extend this approach to other myosin motors, including myosins IIA, I and V. Through use of isoform-specific oligonucleotides and antibodies, we will establish the roles of myosin motors in the growth cone motility of neuroblastoma cells and primary explant neurones.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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