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Structure and function of the nicotinic acetylcholine receptor: molecular dissection of the desensitised binding sites
Reference
C12640
Principal Investigator / Supervisor
Dr Richard Prince
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
214,854
Status
Completed
Type
Research Grant
Start date
24/01/2000
End date
15/05/2003
Duration
40 months
Abstract
Nicotinic acetylcholine receptors (AChRs) are the best characterised members of the ligand- gated channel family and act as a model system for studying agonist binding and conformational switching in these proteins. This project aims to identify amino acids in the AChR that mediate agonist selectivity at the desensitised binding sites and to determine how these residues affect ligand binding and channel gating in the resting and open states of the receptor. Our research will integrate site-directed mutagenesis, ligand binding techniques, single channel recording and single channel kinetic analysis.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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