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Effects of acute ischaemia on thalamocortical synaptic transmission in vitro
Reference
C12634
Principal Investigator / Supervisor
Professor John Quinn
Co-Investigators /
Co-Supervisors
Dr John Quayle
Institution
University of Liverpool
Department
Physiology
Funding type
Research
Value (£)
188,544
Status
Completed
Type
Research Grant
Start date
04/09/2000
End date
01/04/2004
Duration
43 months
Abstract
The aim of this project is to investigate the short- (during ischaemic challenges) and long- term (following reperfusion) effects of is ischaemia on thalamocortical (TC) synaptic transmission. Whole-cell patch clamp recordings will be made in deep layers of somatosensory cortex and TC synaptic responses will be evoked by stimulation of the ventrobasal nucleus of thalamus in TC slices. Ischaemic challenges (4-5 min) will be induced by perfusing the slices with 95 percent nitrogen-saturated and glucose free artificial cerebrospinal fluid. These experiments could provide valuable information about ischaemia- induced changes in synaptic transmission and thereby will improve our understanding of the pathophysiology of neurotoxicity in general.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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