Award details

Extracellular matrix regulation of insulin-like growth factors (IGF) signal transduction and apoptosis in the mammary gland

Reference	C12131
Principal Investigator / Supervisor	Professor Melissa Westwood
Co-Investigators / Co-Supervisors	Professor Charles Streuli, Professor Anne White
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	172,656
Status	Completed
Type	Research Grant
Start date	01/08/2000
End date	01/04/2004
Duration	44 months

Abstract

We have discovered that extracellular matrix (ECM) modifies apoptosis via effects on insulin signalling in mouse mammary epithelial cells (MEC). However, IGFs are more likely to be the physiological regulators of mammary apoptosis and we hypothesise that this will depend on interplay between IGFs and ECM. To address this we will: (1) compare how IGFs and insulin regulate signal transduction and survival; (2) determine how IGF binding proteins (IGFBPs) modulate this process; (3) investigate if IGFs regulate integrins in MEC; (4) explore how ECM affects (a) IGF receptor mediated signalling, (b) the phenotypic response of MEC to IGFs and (c) IGFBP actions. Ultimately this work will elucidate the cellular mechanisms controlling mammary gland physiology.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search