Award details

Targeting and insertion of integral peroxisomal membrane proteins in vitro; comparison with PTS1 and PTS2 targeted matrix proteins

Reference	C12039
Principal Investigator / Supervisor	Professor Alison Baker
Co-Investigators / Co-Supervisors
Institution	University of Leeds
Department	Plant Biochemistry & Biotechnology
Funding type	Research
Value (£)	179,128
Status	Completed
Type	Research Grant
Start date	01/03/2000
End date	01/03/2003
Duration	36 months

Abstract

Our own work and that of others indicates that peroxisomal matrix proteins targeted by the PTS1 and PTS2 pathways share some elements of a common protein import machinery. Although a precise description of the mechanism of matrix protein import remains elusive, the identities of some of the key protein components of the machinery are known and work is in hand to provide a more complete biochemical analysis of their function. In contrast knowledge of the targeting signals, mechanisms of insertion and topological determination of integral membrane proteins remains scanty or non-existent. This proposal aims to characterise the targeting and mechanism of insertion of integral peroxisomal membrane proteins with different topologies and to compare their requirements with those of PTS1 and PTS2 targeted matrix proteins.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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