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Receptor/G-protein interaction in cell signalling

Reference	C11952
Principal Investigator / Supervisor	Professor Philip Gordon Strange
Co-Investigators / Co-Supervisors
Institution	University of Reading
Department	Animal and Microbial Sciences
Funding type	Research
Value (£)	175,468
Status	Completed
Type	Research Grant
Start date	01/01/2000
End date	02/04/2003
Duration	39 months

Abstract

This project will investigate one of the fundamental issues in modern pharmacology, namely how do drugs signal via receptors. Specifically, the interaction of D2 dopamine receptors and G-proteins will be examined after co-expression in insect cells using the baculovirus system. Different isoforms of the receptor (R) and the G-proteins (G) will be expressed at different ratios in order to generate membranes with defined species and levels of the different signalling proteins. Two overall questions will be addressed: (i) how does the R/G ratio and the isoform of R and G affect the potency, maximal effect and amplification for an agonist and the pharmacological profile of the response? (ii) do R and G interact as monomers or do they form higher order arrays and does this affect function?

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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