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Regulation of ARF signalling by 3-phosphorylated inositol lipids
Reference
C11918
Principal Investigator / Supervisor
Professor Peter Cullen
Co-Investigators /
Co-Supervisors
Professor Venkateswarlu Kanamarlapudi
Institution
University of Bristol
Department
Biochemistry
Funding type
Research
Value (£)
177,836
Status
Completed
Type
Research Grant
Start date
01/01/2000
End date
01/01/2003
Duration
36 months
Abstract
The fundamental role of 3-phosphorylated inositol lipids, particularly phosphatidylinositol 3,4,5-trisphospate (PIP3), in the activation of intracellular signalling pathways is becoming increasingly evident. Recently we, and others, have identified ADP-ribosylation factor (ARF) guanine nucleotide exchange factors and ARF GTPase-activating proteins as potential in vivo PIP3 receptors; data that highlights a potential role for PIP3 in the regulation of ARF signalling. Since ARF signalling is linked to a critical role in eukaryotic vesicle trafficking we hereby propose a model implicating PIP3 in the regulation of ARF induce vesicle fusion at the plasma membrane. Experiments described within this proposal are aimed at proving this model.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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