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Regulation of the actin cytoskeleton by WASp-family proteins
Reference
C11829
Principal Investigator / Supervisor
Professor Laura Machesky
Co-Investigators /
Co-Supervisors
Institution
University of Birmingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
182,580
Status
Completed
Type
Research Grant
Start date
05/04/2000
End date
05/04/2003
Duration
36 months
Abstract
Cell motility and morphology are regulated in a large part by signals from outside of the cell which alter the dynamics of the acting cytoskeleton. Many of the signals are now known, as are many of the cytoskeletal proteins which they affect; but molecular pathways connecting actin reorganisation to signalling are largely unknown. We have found a direct connection between a family of adapter proteins, the Wiskott-Aldrich Syndrome protein family, and a complex of cytoskeletal proteins, the Arp2/3 complex, that organise actin at the leading edge of cells. Our studies may help to explain the phenotypes of Wiskott-Aldrich Syndrome patients and may provide the first complete molecular link between signals and actin polymerisation.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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