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A functional approach to the study of a novel GABA receptor subunit
Reference
C11735
Principal Investigator / Supervisor
Professor Richard Ffrench-Constant
Co-Investigators /
Co-Supervisors
Institution
University of Bath
Department
Biology and Biochemistry
Funding type
Research
Value (£)
168,172
Status
Completed
Type
Research Grant
Start date
01/09/1999
End date
01/09/2002
Duration
36 months
Abstract
This proposal describes studies on the function of a novel GABA receptor subunit gene Rdl, which we have coned via a Drosophila mutant resistant to picrotoxinin (PTX) and cyclodiene insecticides. Resistance is associated with replacements of a single amino acid, alanine 302. The objectives of this proposal are: (1) to examine the effect of different replacements of alanine302 on both drug binding and alteration in the rate of receptor desensitisation, both of which appear to be involved in PTX resistance; (2) to determine if Rdl is expressed as a homo- or hetero-multimer in vivo; (3) to characterise the distribution of other GABA receptor-like subunits in the insect nervous system via in situ hybridisation and immunocytochemistry, and to determine if their distributions overlap those of Rdl.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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