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Location and control of endomembrane calcium release channels in plants
Reference
C11712
Principal Investigator / Supervisor
Professor Dale Sanders
Co-Investigators /
Co-Supervisors
Institution
University of York
Department
Biology
Funding type
Research
Value (£)
191,580
Status
Completed
Type
Research Grant
Start date
01/11/1999
End date
01/11/2002
Duration
36 months
Abstract
Mobilisation of intracellular Ca2+ during signalling is well-established in plants, although many of the properties of the Ca2+ channels which underlie these responses remain to be explored. This is exemplified by our recent discovery of a hitherto unsuspected Ca2+ release pathway in plants activated by nicotinic acid adenine dinucleotide phosphate (NAADP), in addition to those pathways activated by InsP3 and cADPR. Using both biochemical and electrophysiological approaches we will (i) establish the membrane location of channels activated by InsP3, cADPR and NAADP; (ii) investigate their potential for regulation, especially by phosphorylation; (iii) characterise the control of cADPR and NAADP production from their respective substrates, NAD and NADP.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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