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Dissection of the role of protein kinase B in apoptosis using isoform specific probes
Reference
C11562
Principal Investigator / Supervisor
Dr G Sale
Co-Investigators /
Co-Supervisors
Institution
University of Southampton
Department
Centre for Biological Sciences
Funding type
Research
Value (£)
157,064
Status
Completed
Type
Research Grant
Start date
21/12/1999
End date
20/05/2003
Duration
41 months
Abstract
Understanding the molecular mechanism of apoptosis is of wide ranging importance because it constitutes the major form of physiological cell death and because suppression or induction of apoptosis contributes to or underlies many disease states. PKB (protein kinase B) has recently been implicated as a key regulator protein that controls apoptosis, although direct demonstration of this has not been made. Additionally, the mechanism by which PKB may prevent apoptosis and the role of different PBK isoforms (alpha, beta and gamma) in the process is unclear. The aim is to use isoform specific probes against PKB, which we have developed, to test and dissect the role of endogenous PKB and its isoforms in preventing apoptosis and to elucidate the targets and signal transduction pathways involved.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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