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Synaptic plasticity in the CNS: the role of Rac and Rho

Reference	C11307
Principal Investigator / Supervisor	Professor Brian Morris
Co-Investigators / Co-Supervisors	Professor Trevor Stone
Institution	University of Glasgow
Department	Institute of Biomedical & Life Sciences
Funding type	Research
Value (£)	178,108
Status	Completed
Type	Research Grant
Start date	15/11/1999
End date	15/11/2002
Duration	36 months

Abstract

Most of the information of the function of small GTP-binding proteins of the Rho family derives from studies using cell lines, where Rho, and the related protein Rac, regulate cell morphology - through interactions with the cytoskeleton - and gene expression - via induction of genes containing multiple serum-response element (SRE) motifs. While Rho, Rac and related proteins are present in the CNS, their function in neurones remains obscure. However, long-term synaptic plasticity in brain regions such as the hippocampus and cerebellum is associated with alterations in neuronal morphology and induction of genes such as zif/268 which contain multiple SREs. This project therefore aims to test the hypothesis that Rho/Rac family GTPases play a pivotal role in synaptic plasticity in the hippocampus and cerebellum.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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