Award details

Molecular mechanism and modulation of expression of P-glycoprotein a plasma membrane transporter

Reference	C11210
Principal Investigator / Supervisor	Professor Peter Anthony McNaughton
Co-Investigators / Co-Supervisors	Dr Alessandro Sardini
Institution	University of Cambridge
Department	Pharmacology
Funding type	Research
Value (£)	240,050
Status	Completed
Type	Research Grant
Start date	10/02/1999
End date	10/01/2003
Duration	47 months

Abstract

The multidrug resistance protein, also known as the P-glycoprotein (P-gp), transports hydrophobic substances across the cell membrane. The mechanism of transport is poorly understood, and one aim of this project is to use a molecular approach to tackle this problem. A recently discovered prokaryotic P-gp homologue, LmrA, which is functionally very similar to P-gp but consists of only one half of the P-gp molecule, will be used to investigate the functional relationship between the two homologous halves of P-gp. Secondly, we have recently discovered that P-gp expression peaks during cell division and falls during interphase. We want to understand the basis of this modulation of P-gp expression, with a view to understanding in a more general sense the regulation of expression of membrane proteins during the cell cycle.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	BioImaging (BI) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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