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Perturbation of membrane dynamics during apoptosis

Reference	C11195
Principal Investigator / Supervisor	Professor Viki Allan
Co-Investigators / Co-Supervisors	Professor Philip Woodman
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	300,251
Status	Completed
Type	Research Grant
Start date	01/03/1999
End date	01/03/2002
Duration	36 months

Abstract

Apoptosing cells undergo remarkable functional changes prior to phagocytosis by neighbouring cells, including alterations in organelle structure and function. One possibility is that compromising the specificity of membrane fusion coupled with changes in organelle motility lead to the widespread fusion of organelles which normally remain distinct, and organelles with the cell surface. We will use video microscopy in combination with organelle-specific green fluorescent protein markers to determine whether such an inappropriate fusion does occur, and the mechanisms involved. In addition, by combing high resolution differential interference contrast or phase contrast microscopy with fluorescence microscopy of living cells, we will be able to order specific changes in membrane structure in relation to the timing of other cellular events.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	BioImaging (BI) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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