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Functional significance of CD40 expression in hepatocytes and intrahepatic endothelium

Reference	C11113
Principal Investigator / Supervisor	Dr Simon Afford
Co-Investigators / Co-Supervisors	Professor David Adams, Professor Lawrence Young
Institution	University of Birmingham
Department	Medical Sciences - Medicine
Funding type	Research
Value (£)	169,402
Status	Completed
Type	Research Grant
Start date	01/07/1999
End date	14/08/2002
Duration	37 months

Abstract

We propose that CD40 plays a crucial immunoregulatory role in the liver by promoting apoptosis of hepatocytes via a novel mechanism in which signalling through hepatocyte CD40 induces apoptosis via autocrine expression of FasL. In contrast CD40 ligation on intrahepatic endothelial cells does not cause apoptosis but activates the endothelium to express adhesion molecules and chemokines that may promote effector cell recruitment. In the proposed studies we shall investigate the functional consequences of CD40 activation in hepatocytes and hepatic endothelial cells to determine how signalling through this receptor can have such different consequences. The studies will determine 1) its role in regulating apoptotic death of hepatocytes and 2) how CD40 modulates leukocyte recruitment to the liver.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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