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Signalling pathways activated by Shc phosphorylation
Reference
C11091
Principal Investigator / Supervisor
Professor Stephen Dilworth
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Dept of Medicine
Funding type
Research
Value (£)
150,130
Status
Completed
Type
Research Grant
Start date
01/07/1999
End date
07/01/2003
Duration
42 months
Abstract
The novel signalling pathways initiated by phosphorylation of two adjacent tyrosines in the Shc proteins are to be identified and characterised. Polyoma MT will be used to provide constitutive activation of this region within cells and in vitro. By inserting altered Shc sequences into mutant MT, the residues required to generate these signals will be established. The molecules that bind to this region, and so initiate these signals, are then to be isolated by 2D gel electrophoresis and molecular biology approaches. A unique in vitro system will enable the interactions involved to be characterised, and the functional roles of these signalling pathways will be determined through use of cells that differentiate or apoptose in response to MT.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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