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The role of platelet/endothelial cell adhesion molecule-1 in cell adhesion and signal- transduction in collagen-stimulated platelets

Reference	C11081
Principal Investigator / Supervisor	Professor Jonathan Gibbins
Co-Investigators / Co-Supervisors
Institution	University of Reading
Department	Animal and Microbial Sciences
Funding type	Research
Value (£)	177,663
Status	Completed
Type	Research Grant
Start date	01/08/1999
End date	01/10/2002
Duration	38 months

Abstract

We propose to investigate the role of platelet/endothelial cell adhesion molecule-1 (CD31) in activation of platelets by collagen, and the effect that tyrosine phosphorylation of CD31 may have on platelet adhesion to collagen. Using biochemical techniques we will identify the receptor and signal transduction mechanisms which led to tyrosine phosphorylation of CD31 following engagement of the activatory collagen receptor. We will study the relationship between the tyrosine phosphorylation of CD31, platelet function and regulation of adhesion to collagen via integrin alpha 2 beta 1. The ligand-binding properties of CD31 on platelets, and the participation of CD31-ligand binding in platelet activation and adhesion, will be investigated using soluble fusion proteins containing extracellular domains on CD31 and CD38, and using receptor domain-specific antibodies

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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