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Structural and functional modifications of translation initiation factors eIF4A and eIF4G in foot and mouth disease virus infected cells

Reference	C11079
Principal Investigator / Supervisor	Professor Christopher Proud
Co-Investigators / Co-Supervisors	Professor Graham Belsham
Institution	University of Dundee
Department	College of Life Sciences
Funding type	Research
Value (£)	166,108
Status	Completed
Type	Research Grant
Start date	12/04/1999
End date	12/04/2002
Duration	36 months

Abstract

The translation initiation factor eIF4F consists of the protein eIF4E, eIF4A and eIF4G. This complex has a critical role in the initiation of cellular cap-dependent protein synthesis. It has also been established that eIF4A and a region of eIF4G are required for translation of picornavirus RNA by a cap-independent mechanism. It has previously been shown that eIF4G is cleaved by the foot-and-mouth disease virus (FMDV) Leader protease. Our new data indicate that eIF4G is also cleaved by the viral 3C protease at distinct sites in vivo. Furthermore the 3C protease also induces the cleavage of eIF4A. We propose to precisely define the novel modifications of these two initiation factors and to determine the effects of the cleavage events on their properties and their roles in cap-dependent and FMDV-RNA directed translation.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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