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Two distinct regulated exocytotic pathways in rat pancreatic acinar cells
Reference
C11044
Principal Investigator / Supervisor
Dr Paul Thomas
Co-Investigators /
Co-Supervisors
Professor John Edwardson
Institution
University of Cambridge
Department
Pharmacology
Funding type
Research
Value (£)
194,538
Status
Completed
Type
Research Grant
Start date
01/06/1999
End date
01/06/2002
Duration
36 months
Abstract
(1) We will determine whether rat pancreatic acinar cells have two distinct, regulated pathways for membrane insertion into the cell surface; one pathway involving the exocytosis of zymogen granules, and another involving an as-yet-uncharacterised vesicle population; (2) We will determine whether the two populations of vesicles are inserted into distinct regions of the cell surface, i.e., apical and basolateral; (3) We will investigate whether the two pathways make use of two distinct sets of SNARE proteins. In these studies we will use a combination of electrophysiological, fluorescence, photochemical and molecular biological techniques to monitor, regulate and manipulate exocytosis in single acinar cells.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
BioImaging (BI) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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