BBSRC Portfolio Analyser
Award details
Determining the function of a novel interferon stimulated gene (BEST5) expressed during bone formation
Reference
C11029
Principal Investigator / Supervisor
Professor T M Skerry
Co-Investigators /
Co-Supervisors
Institution
University of York
Department
Biology
Funding type
Research
Value (£)
52,930
Status
Completed
Type
Research Grant
Start date
01/12/1998
End date
01/12/1999
Duration
12 months
Abstract
We have identified a novel interferon induced gene (BEST5) which is expressed predominantly in bone and spleen, and whose expression is highly regulated during bone mineralisation by primary rat osteoblasts. Our antibody to BEST5 localised protein expression in bone specifically to periostial cells, osteoblasts and fibrocartilage. Both interferon-alpha and -gamma induce the expression of BEST5 in bone cells, although with different kinetics, indicating that interferons may be regulators of BEST5 in vivo. In this project we wish to determine the functional characteristics of BEST5 by investigating regulation of its expression in vitro, in vivo and during embryological development. Subcellular localisations and in vitro over/under expression studies will be followed by generation of BEST5 null mice to provide unequivocal answers on the role of BEST5 in bone remodelling.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search