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Award details
Spectral tuning of violet- and ultraviolet- sensitive visual pigments of vertebrates
Reference
C11013
Principal Investigator / Supervisor
Professor David Hunt
Co-Investigators /
Co-Supervisors
Professor James Bowmaker
Institution
University College London
Department
Institute of Ophthalmology
Funding type
Research
Value (£)
235,616
Status
Completed
Type
Research Grant
Start date
01/05/1999
End date
01/05/2002
Duration
36 months
Abstract
The project will examine the mechanism of spectral tuning of violet- and UV-sensitive visual pigments in vertebrates. This will involve a study of protonation of the Schiff base in violet- and UV-sensitive pigments and the identification of amino acid substitutions responsible for the tuning of violet- and UV-sensitive pigments. Mutant pigments will be generated by site- directed mutagenesis and expressed either by transient transfection of COS cells and by infection of insect cells with recombinant baculovirus.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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