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Regulation of preadipocyte differentiation by specific protein kinase C isoforms
Reference
C10861
Principal Investigator / Supervisor
Dr Neil Anderson
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
147,684
Status
Completed
Type
Research Grant
Start date
01/03/1999
End date
31/08/2002
Duration
42 months
Abstract
A more complete understanding of the molecular regulation of preadipocyte differentiation may lead to novel strategies for controlling obesity. During the differentiation of 3T3-F442A preadipocytes, a well-defined model of mammalian preadipocyte differentiation, we have found that certain isoforms of protein kinase C (PKC) are required at distinct stages of the process. This project aims to determine 1) the changes in the subcellular distribution patterns and catalytic activities of PKC isoforms during preadipocyte differentiation, 2) the molecular basis for the regulation of clonal expansion of immature adipocytes by PKC-gamma and 3) the molecular basis for regulation of terminal differentiation by PKC-epsilon.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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