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Identification and characterisation of signals for self-renewal and differentiation in haemopoietic stem cells
Reference
C10169
Principal Investigator / Supervisor
Professor Anthony David Whetton
Co-Investigators /
Co-Supervisors
Professor Simon James Gaskell
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
226,628
Status
Completed
Type
Research Grant
Start date
01/10/1998
End date
01/10/2001
Duration
36 months
Abstract
Haemopoietic stem cells give rise to all blood cell types and are characterised by their ability to either undergo self-renewal or differentiation to form lineage committed cells. The project objective is to define the molecular events associated with self-renewal and differentiation with the eventual aim of manipulating haemopoietic stem cells ex vivo for clinical use. A murine haemopoietic progenitor cell line transfected with human cytokine receptors has been developed as a model system in which to study signal transduction pathways associated with self-renewal and differentiation. We wish to characterise and define the function of such signalling proteins.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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