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Functional studies of the chemokine receptor CCR-5

Reference	C10164
Principal Investigator / Supervisor	Professor Philip Gordon Strange
Co-Investigators / Co-Supervisors
Institution	University of Reading
Department	Animal and Microbial Sciences
Funding type	Research
Value (£)	283,625
Status	Completed
Type	Research Grant
Start date	01/04/1999
End date	01/09/2002
Duration	41 months

Abstract

In this project we intend to analyse the function of the chemokine receptor CCR-5, which has recently been shown to be the co-receptor for HIV, in native systems and recombinant cell lines using ligand binding and [35S]GTP gamma 5 binding assays. Interaction of CCR-5 with G-proteins, CD4 and other cell surface molecules will be examined in terms of CCR-5 receptor function. It seems likely that CCR-5 exists in an oligomeric form within a mulitprotein complex involving CD4, the presence of such complexes on various cell types will be analysed by protein chemical methods and the allosteric effects of gp120 and CD4 on CCR-5 function assessed. In addition, cell surface molecules whose expression appears to be regulated by CCR-5 co-expression will be studied.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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