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A putative mammalian aspartic proteinase involved in apoptosis
Reference
C09929
Principal Investigator / Supervisor
Professor John Kay
Co-Investigators /
Co-Supervisors
Professor Colin Berry
Institution
Cardiff University
Department
School of Biosciences
Funding type
Research
Value (£)
42,572
Status
Completed
Type
Research Grant
Start date
16/03/1999
End date
15/09/2000
Duration
18 months
Abstract
Two 1998 Nature papers identified a caspase-activated deoxyribonuclease (CAD) together with an inhibitor (ICAD) which regulated the activity of CAD in apoptosis. Within the predicted amino acid sequence of ICAD but apparently unnoticed by the original authors, two hallmark motifs of an aspartic proteinase are present, suggesting that ICAD may be a precursor form of an aspartic proteinase and so may well contain intrinsic proteolytic activity. This proposal requests pump-priming funds in order to provide unequivocal proof of this concept and thus indicate whether such an activity may contribute to the complexity of proteolytic events that mediate apoptosis.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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