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The role of AAA proteases in the functional assembly of photosystem I

Reference	C09815
Principal Investigator / Supervisor	Professor Nicholas Mann
Co-Investigators / Co-Supervisors	Professor Conrad Mullineaux, Professor Colin Robinson
Institution	University of Warwick
Department	Biological Sciences
Funding type	Research
Value (£)	173,739
Status	Completed
Type	Research Grant
Start date	04/01/1999
End date	04/01/2002
Duration	36 months

Abstract

A FtsH proteins are members of a newly identified and widely distributed superfamily of proteins, the AAA proteases, involved in a wide variety of cellular activities. Four ftsH genes have been identified in the genome of the cyanobacterium Synechocystis sp. and at least one of them is implicated in the assembly of the photosystem I (PSI) complexes in the thylakoids. The proposed research will investigate the role(s) of the FtsH homologues in the synthesis of PSI components, assembly into functional PSI complexes and degradation of unassembled components. The experimental approaches will involve an immunological approach to both topological mapping of the FtsH proteins and analysis of the assembly of PSI complexes by pulse-chase experiments coupled with biophysical analysis of PSI functionality.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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