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Mechanisms of protein and signal molecule recognition in eukaryotic signal transduction

Reference	C09717
Principal Investigator / Supervisor	Professor Alastair Hawkins
Co-Investigators / Co-Supervisors	Professor John Coggins
Institution	Newcastle University
Department	School of Cell and Molecular Biosciences
Funding type	Research
Value (£)	164,503
Status	Completed
Type	Research Grant
Start date	01/02/1999
End date	01/09/2002
Duration	42 months

Abstract

We propose to determine the mechanisms of signal transduction in a tractable 3 component eukaryotic pathway. The three components are a surface receptor (a permease), and two carrier molecules. One of the carriers is a transcription repressing protein (QUTR), and the other is a transcription activating protein (QUTA) of the 6 Cys type, which together control the expression of the quinic acid utilisation gene cluster in Aspergillus nidulans. The repressor protein can recognise, and is inactivated by binding, small organic pathway specific metabolites and also interacts directly with the transcription activating protein to inhibit its activity. This proposed research will test experimentally a model for the mechanisms of the specific metabolite recognition and protein:protein interaction which are necessary for transduction of the signal in this system.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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