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Insertion mechanisms for polytopic thylakoid membrane proteins
Reference
C09633
Principal Investigator / Supervisor
Professor Colin Robinson
Co-Investigators /
Co-Supervisors
Professor Stephen High
Institution
University of Warwick
Department
Biological Sciences
Funding type
Research
Value (£)
166,787
Status
Completed
Type
Research Grant
Start date
01/11/1998
End date
01/11/2001
Duration
36 months
Abstract
The aim of this research is to understand how complex membrane proteins are efficiently inserted into the chloroplast thylakoid membrane. Recent research in the PA's lab has shown that two related chlorophyll-binding proteins are inserted by totally distinct mechanisms, one requiring signal recognition particle, GTP and protein translocation apparatus, whereas the other requires none of these factors. We will determine the insertion requirements for other members of this family (months 1- 6), define the molecular signal recognised by SRP and determine the role of SRP in the insertion process (months 7-24). We will then determine the role of the Sec apparatus in the insertion of SRP-dependent and -independent membrane proteins (months 25-36).
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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