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Analysis of a new CD23 receptor in a human B lymphoid cell line

Reference	C09627
Principal Investigator / Supervisor	Professor William Cushley
Co-Investigators / Co-Supervisors
Institution	University of Glasgow
Department	IBLS Division of Biochemistry & Molecula
Funding type	Research
Value (£)	157,044
Status	Completed
Type	Research Grant
Start date	18/05/1998
End date	25/10/2001
Duration	41 months

Abstract

We have recently described the existence of a novel receptor for the CD23 molecule in a human B lymphoid cell line (SMS-SB); stimulation of this receptor appears to rescue the cells from apoptosis. The novel receptor binds both full length and soluble forms of CD23, and is distinct from the currently accepted CD23 receptors, namely CD21 and the beta 2 integrins CD11b-CD18 and CD11c-CD18. This project aims to isolate the CD23 receptor components by biochemical means to enable cloning of receptor cDNAs. The patterns of expression of the novel receptor in haematopoietic cells will be determined and the biological consequences of stimulating this receptor assessed.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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