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Trans-membrane alpha-helices in lipid bilayers: Golgi retention signals and protein functional changes
Reference
C09598
Principal Investigator / Supervisor
Professor Anthony Lee
Co-Investigators /
Co-Supervisors
Institution
University of Southampton
Department
Centre for Biological Sciences
Funding type
Research
Value (£)
185,936
Status
Completed
Type
Research Grant
Start date
09/07/1998
End date
09/07/2001
Duration
36 months
Abstract
We will study the interactions of hydrophobic, trans-membrane alpha-helices with lipid bilayers as a function of peptide structure and bilayer thickness, using recently developed fluorescence methods. The results of these studies will be related to the problem of retention in the Golgi apparatus and the mechanism of the dependence of the activity of membrane proteins on bilayer structure. We will develop a new fluorescence quenching method to quantitate dimer formation by peptides in a lipid bilayer, and study dimer formation as a function of peptide structure and bilayer thickness.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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