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X-ray crystallographic studies of cyclin-dependent kinases

Reference	C09592
Principal Investigator / Supervisor	Professor Ernest Laue
Co-Investigators / Co-Supervisors	Professor Sir Tom Blundell
Institution	University of Cambridge
Department	Biochemistry
Funding type	Research
Value (£)	186,794
Status	Completed
Type	Research Grant
Start date	01/10/1998
End date	01/10/2001
Duration	36 months

Abstract

The aims of this project are: (1) to determine the structure of the p19/Cdk6 complex using X-ray crystallography; (2) to attempt cystallisation of cyclin D/Cdk6 both on its own and with inhibitors; (3) to attempt to express and purify Cdc37, a putative Cdk4/6 chaperone protein, to study its interactions with Cdk6 and, if appropriate, to set up crystallisation trials of that complex, and (4) to use the structural information in an attempt to understand the mechanisms of inhibition of the cyclin D/Cdk6 complex by the Ink4 proteins.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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