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Ultrastructural localisation of nicotinic receptor subtypes in rat striatum and substantia nigra
Reference
C09501
Principal Investigator / Supervisor
Ms Sue Wonnacott
Co-Investigators /
Co-Supervisors
Institution
University of Bath
Department
Biology and Biochemistry
Funding type
Research
Value (£)
144,952
Status
Completed
Type
Research Grant
Start date
01/09/1998
End date
01/09/2001
Duration
36 months
Abstract
Nicotinic acetylcholine receptors (nAChR) are pentameric ligand gated cation channels. Numerous different subunits are expressed in the CNS but the subunit composition and subcellular localisation of nAChR subtypes are largely unknown. This study will use immunocytochemical methods at the light and electron microscope levels to address the distribution, co-localisation and segregation of nAChR subunits. The study will focus on the rat nigro-striatal pathway and striatum, because the modulation of dopamine release in the striatum, locally by presynaptic nAChR and by nAChR in the substantia nigra, is well established. Pre- versus postsynaptic locations, and the spatial relationship of nAChR to cholinergic innervation will be examined. The information gained will provide new insight into the subunit composition and physiological roles of nAChR in the brain.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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