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Folding assembly and degradation of a multi-subunit protein
Reference
C09198
Principal Investigator / Supervisor
Professor Neil Bulleid
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
135,288
Status
Completed
Type
Research Grant
Start date
01/04/1998
End date
01/04/2001
Duration
36 months
Abstract
This project aims to reconstitute two key processes in the biosynthesis of multi-subunit proteins using a semi-permeabilised cell system. These processes, protein folding and assembly in the ER and retrograde transport from the ER to the cytosol for degradation, are fundamental to modern cell biology. They provide a mechanism for the cell to regulate protein expression and secretion, and to ensure that only correctly folded and assembled proteins are transported from the ER to further compartments in the secretory pathway. The project will focus on the biosynthesis of the MHC class I complex due to its well characterised structure and the availability of reagents. Knowledge gained from this study will increase our understanding of how the folding and assembly of multi- subunit proteins occurs within the cell. It will also provide insights into how some viruses evade the immune system by causing the degradation of the MHC class I heavy chain, and could provide a method for screening drugs to inhibit this process.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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