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The role of microtubule-associated protein phosphorylation in regulating plant microtubule dynamics

Reference	C09173
Principal Investigator / Supervisor	Professor Alan Dawson
Co-Investigators / Co-Supervisors	Professor Clive Lloyd
Institution	University of East Anglia
Department	Biological Sciences
Funding type	Research
Value (£)	159,771
Status	Completed
Type	Research Grant
Start date	07/09/1998
End date	07/09/2001
Duration	36 months

Abstract

Our linked research group has shown that microtubules (MTs) are highly dynamic structures that rapidly reorientate in response to extracellular signals. Carrot MT- associated proteins (MAPs) have been isolated and shown to alert MT dynamics in vitro and colocalise to MTs through the cell cycle. Our pilot study has shown that carrot kinases copurify with MAPs and that they phosphorylate plant MAPs. Our data indicate the presence of cyclin-dependent and mitogen-activated protein kinases and support the idea that plant MT dynamics are regulated by MAP phosphorylation via cell cycle- and extracellular signal-dependent kinases. To pursue this work we will investigate: if kinases form complexes with MAPs; which MAPs are phosphorylated; how kinase activities and MAP phosphorylation vary with the cell cycle and in response to plant hormones and how MAP phosphorylation affects MT dynamics.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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