BBSRC Portfolio Analyser
Award details
Regulation of the translation initiation factor complex eIF4F
Reference
C09166
Principal Investigator / Supervisor
Professor Christopher Proud
Co-Investigators /
Co-Supervisors
Institution
University of Dundee
Department
College of Life Sciences
Funding type
Research
Value (£)
177,985
Status
Completed
Type
Research Grant
Start date
06/02/1998
End date
06/12/2001
Duration
46 months
Abstract
The initiation factor complex eIF4F consists of eIF4E (cap-binding protein), eIF4G (scaffolding protein) and eIF4A (helicase which unwinds secondary structure in 5'-UTRs of mRNAs so facilitating their translation). eIF4F plays a key role in regulating translation. eIF4E and eIF4G are phosphoproteins and we recently identified a new protein kinase which phosphorylates eIF4E. This project focuses on the phosphorylation of eIF4E and eIF4G and its role in regulating their functions, eg eIF4F assembly and interaction of eIF4E with inhibitory binding proteins. We will study the phosphorylation sites in eIF4G, use novel approaches to explore roles of different regulatory inputs in controlling eIF4F function and mRNA translation, identify new mRNAs subject to translational control and address the control of translation by cell stresses, which cause dissociation of eIF4F.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search