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The biosynthesis of polytopic integral membrane proteins
Reference
C09159
Principal Investigator / Supervisor
Professor Stephen High
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
153,004
Status
Completed
Type
Research Grant
Start date
01/10/1998
End date
01/10/2001
Duration
36 months
Abstract
The endoplasmic reticulum (ER) is a major site for the production of polytopic plasma membrane glycoproteins in eukarytotic cells. The biosynthesis of these molecules requires the integration of multiple transmembrane domains into the phospholipid bilayer in such a way that these regions can be correctly assembled with one another. Regions of the polypeptide that are translocated across the membrane, and into the lumen of the ER, interact with specific 'molecular chaperones' that can modulate protein folding and maturation. The aims of this project are to investigate these biosynthetic processes and: (i) establish the molecular basis of polytopic transmembrane domain integration; (ii) identify and characterise ER luminal components that facilitate complex maturation events.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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