BBSRC Portfolio Analyser
Award details
Molecular definition of thylakoid targeting signals
Reference
C08676
Principal Investigator / Supervisor
Professor Colin Robinson
Co-Investigators /
Co-Supervisors
Institution
University of Warwick
Department
Biological Sciences
Funding type
Research
Value (£)
141,000
Status
Completed
Type
Research Grant
Start date
01/04/1998
End date
01/04/2001
Duration
36 months
Abstract
The aim of this research is to understand how superficially identical targeting signals direct a specific interaction with one of two totally different protein translocases in the chloroplast thylakoid membrane. Recent work in this lab has revealed the existence of two new types of targeting determinant in the presequences of lumenal proteins. We will define the novel signal for the delta pH-dependent protein transport system, and characterise a second signal that specifically prevents interaction with the thylakoidal Sec apparatus. We will then determine the physiological role of this unique Sec-avoidance signal and test the hypothesis that it has evolved to prevent non-productive interaction of delta pH-dependent substrates with the Sec machinery.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search