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Does maturation-restricted expression of cytosolic phospholipase A2 direct differentiation during B cell development?
Reference
C08624
Principal Investigator / Supervisor
Professor Margaret Harnett
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
Immunology & Bacteriology
Funding type
Research
Value (£)
143,657
Status
Completed
Type
Research Grant
Start date
01/11/1997
End date
01/11/2000
Duration
36 months
Abstract
The immune system has evolved clonal selection mechanisms to prevent the development of B cells which would generate autoreactive antibodies. We have shown that phospholipase A2 (cPLA2) has a maturation-restricted expression using B cell development, being expressed and activated only in B cells undergoing apoptosis, suggesting that cPLA2 could play a key role in B cell repertoire selection. We shall define (i) whether cPLA2 transduces apoptotic signals and (ii) the molecular mechanisms underlying regulation of cPLA2 expression during B cell development.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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