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Endoplasmic reticulum-associated protein degradation in plant cells
Reference
C08612
Principal Investigator / Supervisor
Professor Lynne Roberts
Co-Investigators /
Co-Supervisors
Professor Michael Lord
Institution
University of Warwick
Department
Biological Sciences
Funding type
Research
Value (£)
154,902
Status
Completed
Type
Research Grant
Start date
20/08/1998
End date
14/01/2002
Duration
40 months
Abstract
An important house-keeping function of the plant cell endoplasmic reticulum (ER) is to detect and dispose of aberrant proteins. Very recent work has shown that this involves the export of such proteins from the ER to the cytosol for degradation by the ubiquitin/proteasomal pathway, though the details of this process remain unknown. Using two well characterised plant proteins (ricin and an assembly-defective phaseolin) expressed in tobacco protoplasts, we propose to identify plant ER components involved in this process as a step towards understanding the mechanism(s) involved. Knowledge of this quality control process will be important for understanding how the plant cell handles endogenous proteins and biotechnologically valuable foreign proteins that are delivered into secretory pathway.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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