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Molecular analysis of human splicing complexes
Reference
C08577
Principal Investigator / Supervisor
Professor Angus Lamond
Co-Investigators /
Co-Supervisors
Institution
University of Dundee
Department
College of Life Sciences
Funding type
Research
Value (£)
176,878
Status
Completed
Type
Research Grant
Start date
15/01/1998
End date
05/05/2001
Duration
40 months
Abstract
Pre-mRNA splicing is catalysed by a large RNA-protein complex called the spliceosome. The proposed research centres on the analysis of the protein components of human spliceosomes assembled to utilise alternative 5' splice sites in the pre-mRNA substrate. Although alternative splicing can be brought about by changes in the relative concentration of protein splicing factors or by changes in protein modification, the detailed components and interactions that mediate alternative splicing remain largely unknown. Proteins differentially represented or selectively modified in a spliceosome utilising either one of the alternative splice sites will be identified, cloned, and their role will be probed in functional studies of the in vitro pre-mRNA splicing reaction.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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