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Mechanisms of agonist efficacy
Reference
C08545
Principal Investigator / Supervisor
Professor Philip Gordon Strange
Co-Investigators /
Co-Supervisors
Institution
University of Reading
Department
Animal and Microbial Sciences
Funding type
Research
Value (£)
144,499
Status
Completed
Type
Research Grant
Start date
14/05/1998
End date
14/05/2001
Duration
36 months
Abstract
The project aims to understand one of the fundamental concepts of pharmacology, namely agonist efficacy, at the molecular level, using the 5HT1A serotonin receptor as a model system. Assays will be set up to study the individual steps of the response pathway from agonist binding to response and a wide range of agonists will be tested in ligand binding and functional assays e.g. [35S]GTP gamma S binding. Further experiments will be conducted, including studies on constitutively active mutant receptors to reinforce the conclusions. The importance of hydrogen bond interactions between agonists and the receptor will be examined in order to understand the role of these interactions in the efficacy of agonist signalling.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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