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Award details
Characterisation and identification of an E2F- specific co-repressor which regulates cell-cycle dependant transcription
Reference
C08517
Principal Investigator / Supervisor
Dr Roger Watson
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Dept of Medicine
Funding type
Research
Value (£)
155,683
Status
Completed
Type
Research Grant
Start date
01/02/1998
End date
01/02/2001
Duration
36 months
Abstract
This study will build on our previous finding that E2F-mediated repression of B-myb transcription requires a co-repressor DRS site. The precise nucleotide requirement for DRS repression function will first be established by an extensive mutagenesis strategy, and this information will then be used to characterise DRS-binding proteins in the cell cycle and during differentiation. These studies will form the basis for developing methods to purify the co-repressor factor and eventually to clone its gene. Further effort will also be expended on establishing the generality of this repression mechanism for regulation of gene expression in the cell cycle.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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